https://www.ceesdekker.net Secrets

Halfway by his profession, Cees Dekker reinvented himself. Just after a long time of hardcore physics, he shifted his aim to ‘nanobiology’ on the transform in the millennium. A phrase he coined himself, for a make a difference of actuality.

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Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.

This yielded a breakthrough. In only some months, we have been able to measure transport by a person one-walled carbon nanotube. According to minimal-temperature experiments by an excellent PhD college student in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering by having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes had been legitimate quantum wires with quite prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes

‘At first we looked at Organic units having a Bodily watch and acted on The premise from the equipment we realized. It took a number of years prior to we started out Performing more on the big biological troubles. I then began to contact it nanobiology, a phrase that did not exist at enough time.

Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

2003, shown the initial biosensors produced out of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a new technique for fabricating stable-condition nanopores for DNA translocation

1). The existing–voltage curves showed major modulations with gate voltage, even at space temperature, which was in keeping with band bending inside a ~0.6 eV bandgap semiconducting nanotube. These info also confirmed that the conductance may be modulated by 6 orders of magnitude by shifting the gate voltage. The effects of this operate — a room-temperature transistor created from only one carbon nanotube molecule — had been released in Mother nature in Could 1998.

Screening pseudotopological and nontopological styles for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments

Mother nature Physics thanks the nameless reviewers for their contribution to your peer assessment of the operate.

By way of example, we look at the nucleopore complex, a gateway concerning the cell nucleus and also the cytoplasm. This is a really intricate program and thus tricky to examine inside a mobile, ceesdekker so we use biomimetics. We reconstruct holes then insert person features with the nucleopore sophisticated to check transport as a result of it at The only-molecule amount.’

It absolutely was a very exciting time, all through which I obtained a great deal of guidance from Delft College of Technological know-how, exactly where I used to be a professor at enough time, And that i begun a number of collaborations with molecular biologists. That assisted me understand quite a bit.’